METHOD FOR MONITORING CATHEPSIN S INHIBITION
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Mar 10, 2017
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Sep 18, 2014
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Abstract
The present invention relates to a method for monitoring Cathepsin S inhibitor activity in tissue samples of animals comprising:
- a) providing a tissue sample of an animal to whom a Cathepsin S inhibitor has been administered or providing a tissue sample of an animal that was contacted in vitro with a Cathepsin S inhibitor, wherein the tissue samples comprise white blood cells,b) measuring li p10 peptide level in white blood cells of the tissue sample of step a) by flow cytometry andc) correlating li p10 peptide level in white blood cells to Cathepsin S inhibitor dose, wherein a Cathepsin S inhibitor leads to increased level of li p10 peptide in the white blood cells.
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