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Abstract

Systems and methods for performing DNA sequencing. An example system includes a flow cell, a mechanism to generate fluid flow, a number of reservoirs for containing respective fluids, and a number valves configured such that fluid from any particular one of the plurality of reservoirs can be individually supplied to the flow cell under the impetus of the mechanism to generate fluid flow by opening of the respective valve of the particular reservoir and closing the other valves. Fluids containing test nucleotides may be sequentially flowed through the flow cell and the flow cell imaged at each step to detect binding of the test nucleotides to a sample. The nucleotide sequence of the sample is derived from the images. The sample may be arrayed on a sensing surface of a prism, and the images may be obtained, for example, by surface plasmon resonance imaging (SPRi) of the sensing surface or other techniques.

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