HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 ANTIBODIES

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United States of America Patent

APP PUB NO 20170190785A1
SERIAL NO

15462758

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.

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Patent Owner(s)

Patent OwnerAddress
E R SQUIBB & SONS L L CROUTE 206 AND PROVINCE LINE ROAD PRINCETON NJ 08540

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brams, Peter Sacramento, US 79 1492
Cardarelli, Josephine M San Carlos, US 69 2845
Holmes, Eric H Bothell, US 21 312
VISTICA, Cynthia A Dublin, US 7 34
Witte, Alison Rogue River, US 33 353

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