Method for preparing dabigatran etexilate intermediate, and intermediate compound

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United States of America Patent

PATENT NO 10112901
APP PUB NO 20170190666A1
SERIAL NO

15323709

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Abstract

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Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRYSHANGHAI 200040
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTDNO 369 YUZHOU SOUTH ROAD LIANYUNGANG JIANGSU PROVINCE LIANYUNGANG CITY JIANGSU PROVINCE 222062
CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRYSHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guo, Meng Lianyungang, CN 96 338
Guo, Yajun Shanghai, CN 18 96
Hu, Mingtong Lianyungang, CN 4 4
Huang, Yu Shanghai, CN 357 4038
Shan, Hanbin Shanghai, CN 12 11
Wang, Duzheng Lianyungang, CN 1 0
Yu, Xiong Shanghai, CN 33 232
Yuan, Zhedong Shanghai, CN 12 14
Zhu, Xueyan Shanghai, CN 18 25

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