A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof

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United States of America Patent

APP PUB NO 20170190656A1
SERIAL NO

15314884

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Abstract

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The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P L A CHINAHAIDIAN DISTRICT BEIJING 100-850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CAO, Ruiyuan Beijing, CN 23 7
LI, Feifei Beijing, CN 87 382
LI, Song Beijing, CN 239 936
LI, Wei Beijing, CN 2284 14552
LI, Xingzhou Beijing, CN 36 62
LONG, Long Beijing, CN 14 6
LUO, Haoming Beijing, CN 2 0
WANG, Lili Beijing, CN 226 1989
WANG, Xiaokui Beijing, CN 33 31
XIAO, Junhai Beijing, CN 56 95
XIE, Yunde Beijing, CN 33 56
ZHENG, Zhibing Beijing, CN 57 84
ZHONG, Wu Beijing, CN 81 100
ZHOU, Xinbo Beijing, CN 56 41

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