Augmented Acid Alpha-Glucosidase For The Treatment Of Pompe Disease
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Dec 29, 2016
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Dec 30, 2015
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Abstract
A method for treating Pompe disease including administration of recombinant human acid α-glucosidase having optimal glycosylation with mannose-6-phosphate residues in combination with an amount of miglustat effective to maximize tissue uptake of recombinant human acid α-glucosidase while minimizing inhibition of the enzymatic activity of the recombinant human acid α-glucosidase is provided.
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