6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor

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United States of America Patent

PATENT NO 10329289
APP PUB NO 20170183342A1
SERIAL NO

15386009

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Abstract

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The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bao, Jianming Shanghai, CN 57 276
Gao, Xiaolei Bridgewater, US 26 134
Knowles, Sandra L Princeton, US 10 39
Li, Chunsing Shanghai, CN 13 33
Lo, Michael Man-Chu Bedminster, US 45 67
Mazzola,, Jr Robert D Stewartsville, US 30 122
Ondeyka, Debra L Fanwood, US 8 38
Stamford, Andrew W Chatham, US 83 753
Zhang, Fengqi Edison, US 28 85

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