NOGO Receptor-Mediated Blockade of Axonal Growth
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United States of America Patent
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app pub date -
Jul 13, 2015
filing date -
Jan 12, 2000
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Abstract
Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.
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