SELF-ASSEMBLING DRUG DELIVERY VEHICLES WITH IONICALLY CROSS-LINKED DRUGS
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United States of America Patent
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app pub date -
Mar 3, 2017
filing date -
Sep 3, 2014
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Abstract
A composition and system for delivering a therapeutic agent is provided. The composition includes a self-assembling peptide ionically cross-linked with a charged therapeutic agent. In the presence of the charged therapeutic agent, the peptide self-assembles to form a nanofibrous hydrogel scaffold, wherein the hydrogel structure is quickly recoverable following a shear stress thereby permitting administration of the composition by syringe-needle or catheter injection. Methods of using the composition is also provided.
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