Method for thoracic vertebral bone density measurement by thoracic quantitative computed tomography

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United States of America Patent

PATENT NO 10695022
APP PUB NO 20170164918A1
SERIAL NO

15442596

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A technique for measuring thoracic vertebral bone density (BMD) and coronary calcium score (CCS). Representatively, BMD was measured and averaged at three consecutive thoracic spines (3T) starting from the left main coronary artery caudally and averaging the results of the measurements at the first, second and third spine regions to obtain a thoracic trabecular bone mineral density measurement. The “reference”, as the 3T BMD value of 30 year old and the piBMD (predicted individual BMD (piBMD) were developed. Based on the “reference”, and piBMD, T and Z score of 3T formula were derived in both genders. The new calibration phantom of TQCT and LQCT was designed. The ratios of CTHU/mg/cc were obtained with varying scanners, which were used to translate the CTHU to density units (mg/cc) in BMD and CCS mass measurement. A processor capable of quantitating both BMD and CCS burden was designed. In image without a calibration phantom, formulas were created to quantitate BMD with a high precision.

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Patent Owner(s)

Patent OwnerAddress
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER1124 WEST CARSON STREET TORRANCE CA 90502-2064

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Budoff, Matthew J Manhattan Beach, US 5 106
Dailing, Christopher A Long Beach, US 3 10
Mao, Song Shou Lakewood, US 3 10

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