ANTI-C4.4A ANTIBODIES AND USES THEREOF

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United States of America Patent

SERIAL NO

15425397

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Abstract

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The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

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Patent Owner(s)

Patent OwnerAddress
BAYER INTELLECTUAL PROPERTY GMBHCREATIVE CAMPUS MONHEIM BLDG 4865 ALFRED-NOBEL-STR 10 MONHEIM 40789

International Classification(s)

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  • 2017 Application Filing Year
  • A61K Class
  • 21227 Applications Filed
  • 12841 Patents Issued To-Date
  • 60.50 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CAO, Yong-Jiang Berlin, DE 2 11
DITTMER, Frank Düsseldorf, DE 21 78
FINNERN, Ricarda Aachen, DE 9 60
FRANZ, Juergen Witten, DE 4 27
GREVEN, Simone Dormagen, DE 47 414
HARRENGA, Axel Wuppertal, DE 25 214
LEDER, Gabriele Berlin, DE 6 11
LINDEN, Lars Düsseldorf, DE 27 234
MAYER-BARTSCHMID, Anke Wülfrath, DE 10 41
STELTE-LUDWIG, Beatrix Wülfrath, DE 59 429
TEBBE, Jan Köln, DE 27 154
WILLUDA, Jörg Glienicke/ Nordbahn, DE 16 73

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Patent Citation Ranking

  • 5 Citation Count
  • A61K Class
  • 45.09 % this patent is cited more than
  • 8 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges763281956782001332911183139501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000

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