Binding inhibitor between TCTP dimer type IGE-dependent histamine releasing factor and receptor thereof, and use thereof

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United States of America Patent

PATENT NO 10703812
APP PUB NO 20170158761A1
SERIAL NO

15382277

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Abstract

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The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structural region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, bronchitis, chronic obstructive pulmonary disease, bronchiectasis, rhinitis, atopic dermatitis, hives (urticaria), hay fever, conjunctivitis, and anaphylaxis; inflammatory diseases such as bronchitis, pneumonia, arthritis, nephritis, psoriasis, dermatitis, Crohn's disease, enteritis, gingivitis, arteriosclerosis, coronary arteritis, hepatitis, Behcet's disease, bladder cancer, prostatitis, pyelonephritis, glomerulonephritis, osteomyelitis, thyroiditis, uveitis, abdominal cavity inflammation, meningitis, pulmonary fibrosis and rheumatoid arthritis; and malaria, and a method for screening for the HRF-related diseases.

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Patent Owner(s)

Patent OwnerAddress
EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATIONEWHA WOMANS UNIVERSITY DAEHYUN-DONG 52 EWHAYEODAE-GIL SEODAEMUN-GU SEOUL 120-750

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kim, Mi Young Seoul, KR 113 986
Kim, Mi-Sun Seoul, KR 11 39
Lee, Hee-Won Seoul, KR 24 213
Lee, Kyunglim Seoul, KR 10 85
Maeng, Jeehye Seoul, KR 1 0
Shin, Dong Hae Seoul, KR 3 0

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