RECOMBINANT CYTOTOXIN AND USE THEREOF
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United States of America Patent
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Jun 1, 2017
app pub date -
Jul 26, 2016
filing date -
Nov 26, 2015
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Abstract
A recombinant cytotoxin is provided. The recombinant cytotoxin of the present invention comprises a cytotoxin, a cell penetrating peptide (CPP), and Asp-Glu-Val-Asp (DEVD) sequence inserted in the cytotoxin. The recombinant cytotoxin can induce a targeting cell into the apoptotic pathway and be cleaved by the enzyme generated from apoptotic pathway. The present invention also provides a method for treating cancer, comprising administrating the recombinant cytotoxin to a subject.
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