NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS
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May 25, 2017
app pub date -
Jul 14, 2015
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Jul 14, 2014
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The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.
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