Stabilised formulations of RNA
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United States of America Patent
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May 18, 2017
app pub date -
Jul 4, 2014
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Jul 4, 2014
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Abstract
The present invention relates to stable low-salt aqueous formulations of particles comprising a polycation, preferably protamine, and RNA, which formulations are preferably isotonic, to pharmaceutical compositions or kits comprising such formulations and to their use in medicine. It further relates to methods for preparing the formulations of the invention and to methods for physically stabilizing particles comprising a polycation, preferably protamine, and RNA.
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