Size-based analysis of cell-free tumor DNA for classifying level of cancer
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United States of America Patent
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Aug 11, 2020
Grant Date -
May 11, 2017
app pub date -
Jan 20, 2017
filing date -
Mar 8, 2012
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Abstract
A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.
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