A Diagnostic Marker For Paget's Disease
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United States of America Patent
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May 11, 2017
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May 21, 2015
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May 21, 2014
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Abstract
The invention relates to an in vitro or in vivo method for diagnosing Paget's disease or bone tumors associated therewith or for determining the predisposition of a subject affected by Paget's disease of bone to develop a bone tumor, the method being based on the detection of a mutation in the nucleotide sequence of the ZNF687 gene or in the amino acid sequence of the protein encoded by the mutated ZNF687 gene. The invention also refers to isolated nucleic acids comprising the mutated nucleotide sequence of the ZNF687 gene or a portion thereof and the encoded amino acid sequences.
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