METHODS FOR PREDICTING ACUTE REJECTION IN HEART RECIPIENTS

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United States of America Patent

SERIAL NO

15125355

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Abstract

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The present invention relates to method for predicting acute rejection in heart recipients. In particular, the present invention relates to a method for predicting acute rejection in a heart recipient comprising the steps consisting of i) determining the expression level (ELi) of at least one miRNAi selected from the group consisting of miR-155, miR-10a, miR-92a and miR-31 in a blood sample obtained from the heart recipient, ii) comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) and iii) and concluding that the recipient has a high risk of developing acute rejection when the level the expression level (ELi) determined at step i) is different (higher or lower) than the predetermined reference level (ELRi).

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Patent Owner(s)

Patent OwnerAddress
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)101 RUE DE TOLBIAC PARIS 75013
UNIVERSITE PARIS DIDEROT - PARIS 75 RUE THOMAS MANN PARIS 75013
UNIVERSITE PARIS DESCARTES12 RUE DE L'ECOLE DE MÉDECINE PARIS 75006
ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)3 AVENUE VICTORIA PA 75004

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DUONG, VAN HUYEN Jean-Paul Paris, FR 1 1
JOUVEN, Xavier Paris, FR 4 6
LOUPY, Alexandre Paris, FR 5 6
TIBLE, Marion Paris, FR 1 1

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