METHOD OF SYNTHESIZING POLYSACCHARIDE CONJUGATES AND METHOD FOR CANCER THERAPY
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United States of America Patent
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Issued Date -
May 11, 2017
app pub date -
Jan 25, 2017
filing date -
Jun 4, 2007
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Abstract
A method of synthesizing a polysaccharide conjugate used for cancer therapy is provided. The method comprises the following steps. A polysaccharide having at least one reactive functional group is provided. The polysaccharide is reacted with at least one monomeric amino acid having an O-group, such that the at least one monomeric amino acid is covalently bound to the polysaccharide by reacting with the reactive functional group to form an amide bond. At least one metal is conjugated to the at least one monomeric amino acid through the O-group so as to form the polysaccharide conjugate. Furthermore, a method for cancer therapy that uses the polysaccharide conjugate obtained by the method above for treatment is also described.
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