Methods for the prediction of a personalized ESA-dose in the treatment of anemia

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United States of America Patent

PATENT NO 10796799
APP PUB NO 20170128532A1
SERIAL NO

15319073

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Abstract

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An integrative pharmacokinetic/pharmacodynamics (PK/PD) ESA-EpoR mathematical model calculates the binding behavior of erythropoiesis stimulating agents (ESA). The invention provides methods for the determining of ESA binding sites in cells or patients suffering from anemia. Knowing the amount of ESA binding sites enables the clinical practitioner to optimize the dosage regimen during a treatment of anemia, in particular in patients suffering from a cancerous disease. Further provided are methods for screening ESAs which have a higher specificity for cells strongly expressing the EPO receptor such as colony forming units-erythroid (CFU-E) cells, and not to cells with a low level of EPO receptor cell surface expression, which is the case in cancer cells. Also provided is a computer implemented method, comprising the use of the mathematical model of the invention.

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Patent OwnerAddress
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTSIM NEUENHEIMER FELD 280 HEIDELBERG 69120

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jarsch, Michael Bad Heilbrunn, DE 23 58
Klingmueller, Ursula Heidelberg, DE 2 0
Raue, Andreas Cambridge, US 4 2
Rodriguez, Gonzalez Agustin Heidelberg, DE 2 0
Schelker, Max Berlin, DE 2 2
Schilling, Marcel Heidelberg, DE 3 3
Steiert, Bernhard Freiburg, DE 4 3
Timmer, Jens Freidburg, DE 5 8

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