SYSTEMS AND METHODS FOR DYNAMICALLY GENERATED GENOMIC DECISION SUPPORT FOR INDIVIDUALIZED MEDICAL TREATMENT
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United States of America Patent
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Mar 25, 2016
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Oct 26, 2015
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Optimization of therapeutic outcomes is disclosed. By analyzing molecular genomic sequence data from an individual relative to a pre-defined knowledge base as well as dynamically generated analyses from comparison to a set of other individuals and molecular genomic sequence data of those other individuals along with their therapeutic history and clinical outcome, medication selection for optimum therapeutic outcomes is achieved. The system determines likelihoods of the desired clinical outcome and adverse event profile derived from both the predefined knowledge base along with the dynamic analysis of large-scale population data (e.g., 1 million clinical profiles including linked genomes or some appropriate sample size of clinical profiles with linked genomes sufficient for statistically-powered analyses), and provides a set of recommendations and alternatives for a clinician based on the patient's profile. In certain instances, the system devises a therapeutic strategy of explicit absence of medical therapy for the purposes of cohort analysis.
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