Mechanochemical platform and sensing methods using DNA origami nanostructures
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United States of America Patent
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Jun 23, 2020
Grant Date -
Apr 20, 2017
app pub date -
Jun 5, 2015
filing date -
Jun 6, 2014
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Abstract
A biosensing platform capable of high throughput mechanochemical biosensing comprising a DNA origami nanostructure having a plurality of slots into which recognition elements are strategically placed and apparatus that senses a change in the origami nanostructure in response to the introduction of a target where the apparatus includes a signal transduction unit and signal sensor which exploits mechanical signals in a recognition element which signal includes one or more mechanical tension or mechanochemical rearrangement event. The nanostructure is preferably a 2-dimensional or 3-dimensional arrangement of tiles linked by locking elements, such as aptamers that will open in response to an event such as exposure to a drug molecule, DNA, RNA or protein target.
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