Multi-lineage hematopoietic precursor cell production by genetic programming
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United States of America Patent
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Dec 15, 2020
Grant Date -
Apr 20, 2017
app pub date -
Oct 20, 2016
filing date -
Oct 20, 2015
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Abstract
The present disclosure generally regards methods and compositions for providing multi-lineage hematopoietic precursor cells from pluripotent stem cells (PSCs). The PSCs comprise an expression construct encoding an ETS/ERG gene, GATA2 and HOXA9. Also provided are methods for providing hematopoietic stem cells capable of long-term engraftment in mammals, such as humans. Further provided are therapeutic compositions including the provided hematopoietic stem cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
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