METHOD FOR DECREASING IMMUNOGENICITY OF PROTEIN AND PEPTIDE
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United States of America Patent
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Apr 13, 2017
app pub date -
Jun 5, 2015
filing date -
Jun 5, 2014
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Abstract
The present invention relates to a method for increasing serum half-life of a protein or peptide and decreasing immunogenicity thereof by site-specifically binding a carrier to a protein or peptide, and to the use thereof. The conjugate of the physiologically active protein or peptide of the present invention can significantly decrease immunogenicity in the human body and thus reduce antibody production rate against the protein or peptide. Therefore, the present conjugate has advantages in that a phenomenon of reduced clinical effects of the physiologically active protein or peptide is low, and it can be effectively used in the development of long-acting formulations having a high safety against the immune response.
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