Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways

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United States of America Patent

PATENT NO 10758526
APP PUB NO 20170095575A1
SERIAL NO

15317079

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Abstract

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The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH9000 ROCKVILLE PIKE BETHESDA MD 20854

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dimitrov, Dimiter Frederick, US 20 63
Saha, Saurabh Wellesley Hills, US 51 217
St, Croix Brad Frederick, US 25 141
Zhang, Xiaoyan M Lexington, US 9 25
Zhu, Zhongyu Frederick, US 64 134
Zudaire, Enrique Germantown, US 17 46

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