Fibroblast growth factor mutants having improved functional half-life and methods of their use
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United States of America Patent
Stats
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Jul 17, 2018
Grant Date -
Apr 6, 2017
app pub date -
Oct 17, 2016
filing date -
May 20, 2009
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.
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International Classification(s)
- 2016 Application Filing Year
- A61K Class
- 19101 Applications Filed
- 13019 Patents Issued To-Date
- 68.16 % Issued To-Date
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- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
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