1 -((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea as a TrkA kinase inhibitor

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United States of America Patent

PATENT NO 10835533
APP PUB NO 20170087156A1
SERIAL NO

15311148

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Abstract

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Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.

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Patent Owner(s)

Patent OwnerAddress
ARRAY BIOPHARMA INC3200 WALNUT ST BOULDER CO 80301

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allen, Shelley Boulder, US 54 561
Andrews, Steven W Boulder, US 121 3409
Baer, Brian Boulder, US 1 6
Crane, Zackary Loveland, US 1 6
Liu, Weidong Superior, US 192 700
Watson, Daniel John Lafayette, US 5 17

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