METHOD AND SYSTEM FOR MICROFILTER-BASED CAPTURE AND RELEASE OF CANCER ASSOCIATED CELLS
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United States of America Patent
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Mar 23, 2017
app pub date -
Sep 19, 2016
filing date -
Sep 17, 2015
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A slotted microfilter is coated with a phase changeable material having a hydrophobic state under a first temperature and a hydrophilic state under a second temperature. An example coating material is poly(N-isopropylacrylamide) (“PIPAAm”). The microfilter can be controlled to switch between a capture state where circulating tumor cells are captured by the microfilter and a release state, where viable tumor cells are released from capture for analysis, e.g., single cell phenotypic and genomic analysis, or for ex vivo culture growth.
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