Selective analysis of modified biological molecules with solid-state nanopores
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United States of America Patent
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Apr 28, 2020
Grant Date -
Mar 23, 2017
app pub date -
May 13, 2015
filing date -
May 13, 2014
priority date (Note) -
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Abstract
In one aspect, methods are described herein for the selective detection and quantitative analysis of biological molecule compositions. A method described herein comprises providing a mixture comprising biological molecules, such as DNA, RNA or proteins, complexed with a translocating agent, such as another DNA or protein, and non-complexed biological molecules. The mixture is contacted with a membrane comprising at least one nanopore and an electric field is applied across the nanopore to selectively translocate the biological molecules complexed with the translocating agent through the at least one nanopore. Concentration of the complexed biological molecules is determined based on the translocation rate of said molecules.
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