ULTRASOUND PRECURSOR PREPARATION METHOD
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United States of America Patent
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Issued Date -
Mar 23, 2017
app pub date -
Mar 31, 2015
filing date -
Mar 31, 2014
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Abstract
The present invention relates to a method of preparation of ultrasound contrast agent precursors comprising phospholipid-stabilised perfluorobutane microbubbles. The method is amenable to commercial scale manufacture, and provides more consistent vial-to-vial yields and size distribution of said microbubbles. Also provided are methods of preparing kits and ultrasound contrast agents using the method of the invention.
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