Modified adenoviruses for cancer vaccines development
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United States of America Patent
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Oct 13, 2020
Grant Date -
Mar 23, 2017
app pub date -
May 18, 2015
filing date -
May 19, 2014
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Abstract
The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g. cancer, by adenoviral vectors which have been coated by polypeptides causing peptide-specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.
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