Method for adjusting the release of active agent in a transdermal delivery system
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United States of America Patent
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Aug 30, 2022
Grant Date -
Mar 23, 2017
app pub date -
May 20, 2015
filing date -
May 20, 2014
priority date (Note) -
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Abstract
The present invention relates to the use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, in which the inner phase includes the additive and an active agent dissolved therein. The additive has a higher affinity to water than to the active agent and controls the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, with the maintenance of the permeation rate being proportional to the amount of active agent in the biphasic layer.
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