Methods for Operating a System Comprising a Coupled Mass Spectrometer and Ion Mobility Spectrometer
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United States of America Patent
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Mar 16, 2017
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Nov 2, 2016
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Jun 13, 2014
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A method of operating a system comprising a chromatograph, an ion source, a mass spectrometer having a mass analyzer and an ion mobility spectrometer interposed between the ion source and the mass analyzer, comprising: performing a first chromatographic and mass analysis of a sample while operating the ion mobility spectrometer in non-dispersive mode, wherein a respective ion-signal-acquisition time (AT) and a corresponding loss-of-ion-signal time (LT) are identified for each detected m/z ratio that corresponds to a precursor-ion m/z ratio of interest; and performing a second chromatographic and mass analysis of the sample during which, for each identified AT and LT, the corresponding respective precursor ion is fragmented to generate product ions and the product ions are detected by the mass analyzer, wherein the ion mobility spectrometer is operated in dispersive mode such that ions of said each respective precursor-ion species are preferentially transmitted therethrough spectrometer to the mass analyzer.
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