PRENATAL THERAPY TO INDUCE IMMUNE TOLERANCE
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United States of America Patent
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Jun 23, 2016
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Jul 2, 2015
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Abstract
Constructs and methods for inducing immune tolerance during gestation, e.g. in utero, are provided. The constructs comprise a moiety that targets and binds to the neonatal Fc receptor (FcRn) and a moiety comprising an antigen of interest for which immune tolerance is desired. Administration of the constructs to a fetus during gestation results in immune tolerance, e.g. to antigens that otherwise elicit an unwanted immune response such as an autoimmune reaction.
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