HUMAN ANTIBODY-PRODUCING CELL

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20170058029A1
SERIAL NO

15308085

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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It is an object of the present invention to provide a chicken B cell that expresses a variety of human antibodies. The solution to the problem in the present invention is a chicken B cell, in which, in an antibody light chain gene locus thereof, all or a part of a DNA sequence derived from a human antibody light chain variable region and a human antibody light chain constant region are inserted, or the antibody light chain gene locus is replaced with all or a part of a DNA sequence derived from a human antibody light chain variable region and a human antibody light chain constant region, and in an antibody heavy chain gene locus thereof, all or a part of a DNA sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region are inserted, or the antibody heavy chain gene locus is replaced with all or a part of a DNA sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region, and in an antibody light chain pseudogene locus thereof, two or more DNA sequences derived from human antibody light chain variable regions are inserted, or the antibody light chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody light chain variable regions, and/or in an antibody heavy chain pseudogene locus thereof, two or more DNA sequences derived from human antibody heavy chain variable regions are inserted, or the antibody heavy chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody heavy chain variable regions.

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Patent Owner(s)

Patent OwnerAddress
CHIOME BIOSCIENCE INCTOKYO 151-0071

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asagoshi, Kenjiro Tokyo, JP 2 3
Hashimoto, Shuichi Tokyo, JP 47 451
Kawata, Shigeshisa Tokyo, JP 1 2
Miyai, Shunsuke Tokyo, JP 2 3
Sano, Hitomi Tokyo, JP 9 181
Sawada, Atsushi Tokyo, JP 23 234
Takahashi, Naoki Tokyo, JP 418 3234
Takesue, Aki Tokyo, JP 3 3
Uchiki, Tomoaki Tokyo, JP 6 3
Yabuki, Takashi Tokyo, JP 7 9

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