MACROCYCLIC FACTOR XIA INHIBITORS CONDENSED WITH HETEROCYCLES
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United States of America Patent
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Issued Date -
Mar 2, 2017
app pub date -
Jan 30, 2015
filing date -
Jan 31, 2014
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Abstract
The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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