CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
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United States of America Patent
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Aug 22, 2014
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Aug 23, 2013
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Abstract
Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism. The compounds include a pyrido[3,2-d]pyrimidine scaffold substituted with aromatic and heteroaromatic moieties.
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