Transposon Activation During Aging and Neuronal Decline
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United States of America Patent
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Feb 16, 2017
app pub date -
Jul 25, 2016
filing date -
Mar 15, 2013
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Abstract
The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.
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