Hybridoma cell lines (My-C-cC0C2-259-1 A4) and use thereof for producing a monoclonal antibody against human cardiac myosin binding protein C (C-protein, MYBPC3, cMyBP-C or My-C)

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United States of America Patent

PATENT NO 10017745
APP PUB NO 20170044501A1
SERIAL NO

15114670

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Abstract

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Monoclonal antibodies, which can be produced in vitro, against cardiac epitopes of the human My-C are produced by generating myeloma cell clones that produce such specific antibodies having epitope specificity. These monoclonal antibodies allow, among other things, the creation of an enzyme-linked immunosorbent assay (ELISA) for the specific, cross-reactivity-free quantitative determination of My-C in serum, plasma, whole blood or other body fluid. Specifically, a hybridoma cell clone producing a monoclonal antibody that detects and binds a cardiac epitope in the My-C is provided, which has no cross-reactivity with respect to the myosin-binding proteins of the skeletal muscles. The hybridoma cell line can be obtained by fusing myeloma cells with spleen cells of a test animal, in particular a mouse, immunized against recombinant My-C.

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Patent Owner(s)

Patent OwnerAddress
KING'S COLLEGE LONDONSTRAND LONDON WC2R 2LS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Medek, Rita Halle, DE 2 0
Weber, Ekkehard Halle, DE 11 118

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