HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE
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United States of America Patent
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Issued Date -
Feb 16, 2017
app pub date -
Aug 12, 2016
filing date -
Dec 28, 2007
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Abstract
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
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