SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS
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United States of America Patent
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Feb 16, 2017
app pub date -
Nov 12, 2014
filing date -
Nov 14, 2013
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Abstract
Described herein are certain steroid derivative compounds, for example of formula (I): wherein X1, X2, X3 L, and Ar are as defined herein, pharmaceutical compositions comprising such compounds, the use of such compounds and compositions to specifically target glucocorticoid action, and the use of such compounds and compositions in the treatment of acute and chronic inflammatory conditions, in particular rheumatoid arthritis, haematological and other malignancies, and for causing immunosuppression in the prevention or treatment of transplant rejection, as well as methods of preparing such compounds.
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