The present invention relates to a spray drying system provided with a neutralizing system, which system is intended for use in the pharmaceutical industry or in other industries, where the product is e.g. infectious, toxic or highly reactive and constitutes a risk for the surroundings and/or a health risk to people handling the product. The spray drying system comprises a spray drying chamber (1) comprising a drying chamber (1) provided with an atomizer device (17), followed by units (2, 3) for collecting of product powder and means (8) for cleaning the exhaust gas, wherein an atomization device (16) connected to a vessel (13) containing a neutralizer agent is placed upstream of the drying chamber (1). The invention also relates to a method which method comprises the following steps: i) sterilizing the spray drying system if the process has to be conducted under aseptic conditions, ii) processing by drying a fluid feed added to a drying chamber (1) through one or more atomization nozzle(s) (16), iii) neutralizing comprising adding a neutralizing agent upstream of the drying chamber (1), iv) cleaning the spray drying system.

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