CHROMATOGRAPHY APPARATUS HAVING DIFFUSION-BONDED AND SURFACE-MODIFIED COMPONENTS
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United States of America Patent
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app pub date -
Aug 8, 2016
filing date -
Mar 26, 2010
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Abstract
A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.
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International Classification(s)
- C23C:COATING METALLIC MATERIAL; COATING MATERIAL WITH M....
- B23B:TURNING; BORING
- B23K:SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLA....
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- B23H:WORKING OF METAL BY THE ACTION OF A HIGH CONCENTRA....
- C23F:NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM S....
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