INHIBITION OF LACTATE DEHYDROGENASE 5 (LDH-5) BINDING, INCORPORATION, INTERNALIZATION AND/OR ENDOCYTOSIS TO IMMUNE CELLS
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United States of America Patent
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Issued Date -
Feb 2, 2017
app pub date -
Apr 7, 2015
filing date -
Apr 9, 2014
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Disclosed are methods of treating cancer in a subject including administering to the subject a therapeutic dose of an agent that inhibits LDH-5 binding to, incorporation, internalization and/or endocytosis into an immune cell. In some alternatives, the agent is an anti-LDH-5 antibody. Some alternatives include a step of detecting LDH-5, or a variant thereof in said subject, and administering to said subject a therapeutic dose of an anti-LDH-5 antibody raised against the amino terminus of said LDH-5 or a variant thereof.
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