Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
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United States of America Patent
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Jan 9, 2018
Grant Date -
Jan 26, 2017
app pub date -
Dec 23, 2014
filing date -
Dec 26, 2013
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Abstract
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, Y, Z, and G are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I), and pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
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