Conjugates of oligomer of hyaluronic acid or of a salt thereof, method of preparation thereof and use thereof
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United States of America Patent
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Jul 17, 2018
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Jan 19, 2017
app pub date -
Mar 10, 2015
filing date -
Mar 11, 2014
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Abstract
The invention relates to conjugates of hyaluronic acid oligomer according to the general formulae I, II III or IV, or a salt thereof, the method of preparation thereof and use thereof, where the oligomer is bonded to the respective substrate by its ending anomeric center via a bi-functional amino linker by means of an amino or imino bond. This type of conjugates allows releasing oligomers in their native form. The prepared systems exhibited an enhanced biological activity against selected lines of cancer cells.
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