Compositions And Methods For Modulating And Redirecting Immune Responses
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United States of America Patent
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Jan 19, 2017
app pub date -
Jan 21, 2015
filing date -
Jan 21, 2014
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Abstract
Provided herein are methods of modulating and redirecting an immune response. Compositions and methods for killing targeted cells in a cell population are also provided wherein, a cell population containing target cells expressing a target associated antigen and T cells are contacted with 1, 2, or more immune checkpoint antagonists and a multispecific T cell-redirecting agent that specifically binds the target associated antigen expressed on the target cells and specifically binds a T cell surface antigen.
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