Orally Disintegrating Tablet of Nabilone Comprising Mannitol-Based Granules
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United States of America Patent
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Issued Date -
Jan 19, 2017
app pub date -
Mar 4, 2015
filing date -
Mar 4, 2014
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Abstract
Orally disintegrating medicaments comprising Nabilone allow for improved treatment of nausea arising from chemo therapy for cancer. The medicaments comprise appropriate excipients such that the medicament disintegrates in the mouth in 30 seconds or less, while exhibiting sufficient stability for storage. In a preferred embodiment, the medicament is in the form of a tablet formed from granules. The granules consist of an intra-granular fraction comprising nabilone, mannitol, and polyvinyl pyrrolidone and an extra-granular fraction comprising mannitol, calcium silicate, crospovidone, and magnesium stearate. Processes for manufacturfing such medicaments are also disclosed.
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