PREPARATION OF N-MONOFLUOROALKYL COMPOUNDS
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Jun 30, 2016
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Dec 17, 2009
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The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodide. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the 123I-labelled radiopharmaceutical DaTSCAN™ (123I-ioflupane). Also provided is the use of fluoroalkyl iodide in the alkylation method of the invention.
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