Cationic neurotoxins
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United States of America Patent
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Mar 20, 2018
Grant Date -
Dec 22, 2016
app pub date -
Jul 9, 2014
filing date -
Jul 9, 2013
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Abstract
The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking said at least one amino acid modification. Also provided are corresponding uses of the engineered clostridial toxin in therapy.
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